Adaptable alginate-based microfibers for 3D in vitro cultures of cancer cells: an anticancer drug testing model Abstract

Glavni sadržaj članka

Jelena Petrović
Elżbieta Pańczyszyn
Marco Corazzari
Ivana Banićević
Milena Milivojević
Luka Bojić
Milena Stevanović
Miodrag Dragoj
Milica Pešić
Radmila Janković
Bojana Obradović
Jasmina Stojkovska

Apstrakt

The slow advance in anticancer drug development can be attributed to the limitations of conventional models, predominantly monolayer cell (2D) cultures and animal models, which inadequately recapitulate the complex nature of human malignant tumors. Three-dimensional (3D) in vitro models are invaluable tools in drug screening; however, creating a universal model for all cancer types poses challenges due to the diverse nature of cancers. The aim of this work was to develop a single, versatile model using alginate microfibers to accommodate cultivation of various cancer cells.

Detalji članka

Rubrika

Cancer research

Kako citirati

[1]
J. . Petrović, “Adaptable alginate-based microfibers for 3D in vitro cultures of cancer cells: an anticancer drug testing model: Abstract”, Hem Ind, vol. 78, no. 1S, p. 21, Mar. 2024, Accessed: Oct. 16, 2025. [Online]. Available: https://www.ache-pub.org.rs/index.php/HemInd/article/view/1264

Funding data

Reference

Panczyszyn, E., Saverio, V., Monzani, R., Gagliardi, M., Petrovic, J., Stojkovska, J., Collavin, L., Corazzari, M. FSP1 is a predictive biomarker of osteosarcoma cells’ susceptibility to ferroptotic cell death and a potential therapeutic target. Cell Death Discov. 2024; 10: 87. https://doi.org/10.1038/s41420-024-01854-2

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