Doxorubicin and quercetin combined effect on SAOS-2 cells grown in 2D and 3D model systems Abstract

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Published: Mar 29, 2024
Keywords:
Osteosarcoma, alginate microbeads, anticancer treatment

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Luka Bojić
niversity of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia
https://orcid.org/0000-0002-1462-4557
Jelena Pejić
University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia
Jasmina Stojkovska
University of Belgrade, Faculty of Technology and Metallurgy, Belgrade, Serbia
https://orcid.org/0000-0002-6732-3037
Milena Stevanović
1University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia, University of Belgrade, Faculty of Biology, Belgrade, Serbia and Serbian Academy of Sciences and Arts, Belgrade, Serbia
Aleksandra Medić
University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia
https://orcid.org/0000-0003-0991-7459
Isidora Petrović
University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia
https://orcid.org/0000-0002-9816-2184
Milena Milivojević
University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia

Abstract

Osteosarcoma (OS) is a highly aggressive primary malignant bone tumor that most commonly affects children, adolescents, and young adults. The standard treatment for OS consists of surgical resection and chemotherapy, whereas radiation therapy is recommended for the unresectable tumor. Due to its easy metastasis and recurrence, the 5-year overall survival rate is only 66.5 %. Thus, there is a critical need to recognize the molecular mechanisms underlying OS development and pathogenesis. Traditionally, two-dimensional (2D) cells are widely used in cancer biology and pre-clinical studies. However, 2D models are unable to mimic cell–cell and cell-extracellular matrix interactions which are crucial for adequate cellular function. Three-dimensional (3D) model systems are able to recapitulate key features of human cancer and are recognized as a promising platform for fundamental and translational research. In the present work, we established an osteosarcoma 3D model based on alginate microbeads and studied the effect of combined treatment with doxorubicin (Doxo), widely used chemotherapeutic, and quercetin (Quer), a plant pigment with anticancer properties, on OS model systems.

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How to Cite
Bojić, L. ., Pejić, J. ., Stojkovska, J. ., Stevanović, M. ., Medić, A. ., Petrović, I. ., & Milivojević, M. . (2024). Doxorubicin and quercetin combined effect on SAOS-2 cells grown in 2D and 3D model systems: Abstract. HEMIJSKA INDUSTRIJA (Chemical Industry), 78(1S), 20. Retrieved from https://www.ache-pub.org.rs/index.php/HemInd/article/view/1262
Issue
Vol. 78 No. 1S (2024): Supplementary Issue - ExcellMater Conference 2024
Section
Cancer research
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References

Dharanikota A, Arjunan R, Dasappa A. Factors Affecting Prognosis and Survival in Extremity Osteosarcoma. Indian J Surg Oncol. 2021;12(1):199-206. doi:10.1007/s13193-020-01277-2

Lovitt, C.J., Shelper, T.B. & Avery, V.M. Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins. BMC Cancer 18, 41 (2018). https://doi.org/10.1186/s12885-017-3953-6

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