Adaptable alginate-based microfibers for 3D in vitro cultures of cancer cells: an anticancer drug testing model Abstract
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Abstract
The slow advance in anticancer drug development can be attributed to the limitations of conventional models, predominantly monolayer cell (2D) cultures and animal models, which inadequately recapitulate the complex nature of human malignant tumors. Three-dimensional (3D) in vitro models are invaluable tools in drug screening; however, creating a universal model for all cancer types poses challenges due to the diverse nature of cancers. The aim of this work was to develop a single, versatile model using alginate microfibers to accommodate cultivation of various cancer cells.
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Funding data
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Horizon 2020
Grant numbers 952033
References
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