Peculiarities of alginate gellation triggered by calcium ions in the presence of hydroxyapatite particles Abstract
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Abstract
Hydroxyapatite (HAP), a crucial constituent of natural bone mineral, significantly enhances the osteoconductivity of alginate hydrogels (AH) in biodegradable composites mimicking the mineral composition, porosity, and mechanical properties of bone tissue. Ionic crosslinking of sodium alginate hydrogels with Ca+ ions result in the rapid formation of egg-box structures, leading to enthalpy-driven hydration and dehydration mechanisms observable through swelling and subsequent shrinkage of the crosslinked aerogel. The fast shrinkage induces non-linear sizing of water-containing pockets, impacting the unilinear pore size distribution of freeze-dried aerogels, thereby influencing the porosity and mechanical properties of the final scaffolds.
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Funding data
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Horizon 2020 Framework Programme
Grant numbers 952033;860462
References
Stojkovska J, Zvicer J, Andrejevic, M, Janackovic D, Obradovic B, Veljovic D. Novel composite scaffolds based on alginate and mg‐doped calcium phosphate fillers: enhanced hydroxyapatite formation under biomimetic conditions. Journal of biomedical materials research part b: applied biomaterials.2021; 109: 2079-2090. https://doi.org/10.1002/jbm.b.34856