Chemotherapy and novel proton radiotherapy in spatially advanced multicellular models of pancreatic cancer: On the design of platform for enabling low cost animal free preclinical treatment testing Abstract
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Abstract
With a 5-year of only 11% pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest diseases. This is partly attributed to the tumour’s resistance to currently available treatment, resulting from a complex and highly heterogeneous tumour microenvironment (TME). A key challenge in cancer tissue engineering is to mimic the different key features of the TME. In this work we have developed robust, PDAC biomimetic models for in vitro therapeutic assessment.
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Funding data
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Medical Research Council
Grant numbers MR/V028553/1
References
Totti S, Allenby MC, Dos Santos SB, Mantalaris A, Velliou E. A 3D bioinspired highly porous polymeric scaffolding system for in vitro simulation of pancreatic ductal adenocarcinoma, RSC Adv. 2018; 8: 20928-20940 https://doi.org/10.1039/C8RA02633E
Gupta P, Totti S, Pérez-Mancera PA, Dyke E, Nisbet A, Schettino G, Webb R, Velliou EG. Chemoradiotherapy screening in a novel biomimetic polymer based pancreatic cancer model. RSC Adv. 2019; 9: 41649-41663 https://doi.org/10.1039/C9RA09123H
Gupta P, Pérez-Mancera PA, Kocher H, Nisbet A, Schettino G, Velliou EG. A novel scaffold-based hybrid multicellular model for pancreatic ductal adenocarcinoma—toward a better mimicry of the in vivo tumor microenvironment. Front. Bioeng. Biotechnol. 2020; 8 (290). https://doi.org/10.3389/fbioe.2020.00290
Gupta P, Bermejo-Rodriguez C, Kocher H, Pérez-Mancera PA, Velliou EG. Chemotherapy assessment in advanced multicellular 3D models of pancreatic cancer: Unravelling the importance of spatiotemporal mimicry of the tumor microenvironment. Adv. Biol. 2024; 2300580. https://doi.org/10.1002/adbi.202300580