Effects of different doped hydroxyapatite‐based materials on healing of critical size calvaria bone defects in rats Abstract

Glavni sadržaj članka

Nikola Busarać
Irena Kasalović
https://orcid.org/0000-0002-3716-4143
Suzana Živanović
Tamara Matić
https://orcid.org/0000-0002-7415-0453
Đorđe Veljović
https://orcid.org/0000-0001-6370-7167
Biljana Ljujić
https://orcid.org/0000-0002-6759-2720
Miloš Papić

Apstrakt

Nanosized synthetic hydroxyapatite (HAp), closely resembling biological apatite found in human bones and teeth, is extensively studied for its potential in hard tissue repair. Ion-doping of HAp with therapeutic ions is emerging as a promising strategy to mimic biological apatite, promoting specific biological responses such as osteogenesis, angiogenesis, increased cell proliferation, and antimicrobial activity. The aim of our study was to explore and compare the effects of Sr,Cu co-doped α tricalcium phosphate (αTCP) with/without Mg doped HAP on healing of critical size rat calvaria defects in vivo.

Detalji članka

Rubrika

Biomaterials for orthopedic and dental applications

Kako citirati

[1]
N. . Busarać, “Effects of different doped hydroxyapatite‐based materials on healing of critical size calvaria bone defects in rats: Abstract”, Hem Ind, vol. 78, no. 1S, p. 38, Mar. 2024, Accessed: Jul. 26, 2025. [Online]. Available: https://www.ache-pub.org.rs/index.php/HemInd/article/view/1282

Reference

Matić T, Zebić ML, Miletić V, et al. Sr,Mg co-doping of calcium hydroxyapatite: Hydrothermal synthesis, processing, characterization and possible application as dentin substitutes. Ceram Int 2022;48(8):11155–65. https://doi.org/10.1016/j.ceramint.2021.12.335

Aroni MAT, de Oliveira GJPL, Spolidório LC, et al. Loading deproteinized bovine bone with strontium enhances bone regeneration in rat calvarial critical size defects. Clin Oral Investig 2019;23(4):1605–14. https://doi.org/10.1007/s00784-018-2588-6

Qin H, Weng J, Zhou B, et al. Magnesium Ions Promote In Vitro Rat Bone Marrow Stromal Cell Angiogenesis Through Notch Signaling. Biol Trace Elem Res 2023;201(6):2823–42. https://doi.org/10.1007/s12011-022-03364-7

Yu X, Guan P-P, Zhu D, et al. Magnesium Ions Inhibit the Expression of Tumor Necrosis Factor α and the Activity of γ-Secretase in a β-Amyloid Protein-Dependent Mechanism in APP/PS1 Transgenic Mice. Front Mol Neurosci 2018; 11. https://doi.org/10.3389/fnmol.2018.00172

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