Citric acid-crosslinked gelatin/hydroxypropyl methylcellulose hydrogels for biomedical applications Abstract
Article Sidebar
Main Article Content
Abstract
Hydrogels, characterized by their three-dimensional hydrophilic polymer networks capable of retaining substantial amounts of water or biological fluids, hold significant promise for biomedical and pharmaceutical applications. While numerous polymers have been explored for hydrogel development, those derived from natural sources possess inherent advantages due to their abundance, affordability, biocompatibility, and biodegradability. Gelatin, a widely used natural polymer in biomedicine, stands out for its cost-effectiveness, compatibility with biological systems, and degradability. Hydroxypropyl methylcellulose (HPMC), a cellulose derivative, exhibits hydrophilicity, biodegradability, and biocompatibility. However, natural polymer-based hydrogels often exhibit low mechanical strength and solubility in physiological conditions, necessitating innovative cross-linking strategies to enhance their functionality. Citric acid (CA) emerges as a promising crosslinking agent owing to its affordability and non-toxic nature.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors grant to the Publisher the following rights to the manuscript, including any supplemental material, and any parts, extracts or elements thereof:
- the right to reproduce and distribute the Manuscript in printed form, including print-on-demand;
- the right to produce prepublications, reprints, and special editions of the Manuscript;
- the right to translate the Manuscript into other languages;
- the right to reproduce the Manuscript using photomechanical or similar means including, but not limited to photocopy, and the right to distribute these reproductions;
- the right to reproduce and distribute the Manuscript electronically or optically on any and all data carriers or storage media – especially in machine readable/digitalized form on data carriers such as hard drive, CD-Rom, DVD, Blu-ray Disc (BD), Mini-Disk, data tape – and the right to reproduce and distribute the Article via these data carriers;
- the right to store the Manuscript in databases, including online databases, and the right of transmission of the Manuscript in all technical systems and modes;
- the right to make the Manuscript available to the public or to closed user groups on individual demand, for use on monitors or other readers (including e-books), and in printable form for the user, either via the internet, other online services, or via internal or external networks.
Funding data
-
Horizon 2020 Framework Programme
Grant numbers 952033
References
-