Citric acid-crosslinked gelatin/hydroxypropyl methylcellulose hydrogels for biomedical applications Abstract

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Vukašin Ugrinović
Maja Marković
Predrag Petrović
Đorđe Veljović


Hydrogels, characterized by their three-dimensional hydrophilic polymer networks capable of retaining substantial amounts of water or biological fluids, hold significant promise for biomedical and pharmaceutical applications. While numerous polymers have been explored for hydrogel development, those derived from natural sources possess inherent advantages due to their abundance, affordability, biocompatibility, and biodegradability. Gelatin, a widely used natural polymer in biomedicine, stands out for its cost-effectiveness, compatibility with biological systems, and degradability. Hydroxypropyl methylcellulose (HPMC), a cellulose derivative, exhibits hydrophilicity, biodegradability, and biocompatibility. However, natural polymer-based hydrogels often exhibit low mechanical strength and solubility in physiological conditions, necessitating innovative cross-linking strategies to enhance their functionality. Citric acid (CA) emerges as a promising crosslinking agent owing to its affordability and non-toxic nature.


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Ugrinović, V. ., Marković, M. ., Petrović, P. ., & Veljović, Đorđe . (2024). Citric acid-crosslinked gelatin/hydroxypropyl methylcellulose hydrogels for biomedical applications: Abstract. HEMIJSKA INDUSTRIJA (Chemical Industry), 78(1S), 29. Retrieved from
Polymer gels and composites for biomedical applications

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