Effects of different doped hydroxyapatite‐based materials on healing of critical size calvaria bone defects in rats Abstract

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Nikola Busarać
Irena Kasalović
Suzana Živanović
Tamara Matić
Đorđe Veljović
Biljana Ljujić
Miloš Papić


Nanosized synthetic hydroxyapatite (HAp), closely resembling biological apatite found in human bones and teeth, is extensively studied for its potential in hard tissue repair. Ion-doping of HAp with therapeutic ions is emerging as a promising strategy to mimic biological apatite, promoting specific biological responses such as osteogenesis, angiogenesis, increased cell proliferation, and antimicrobial activity. The aim of our study was to explore and compare the effects of Sr,Cu co-doped α tricalcium phosphate (αTCP) with/without Mg doped HAP on healing of critical size rat calvaria defects in vivo.


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Busarać, N. ., Kasalović, I. ., Živanović, S. ., Matić, T. ., Veljović, Đorđe ., Ljujić, B. ., & Papić, M. . (2024). Effects of different doped hydroxyapatite‐based materials on healing of critical size calvaria bone defects in rats: Abstract. HEMIJSKA INDUSTRIJA (Chemical Industry), 78(1S), 38. Retrieved from https://www.ache-pub.org.rs/index.php/HemInd/article/view/1282
Biomaterials for orthopedic and dental applications


Matić T, Zebić ML, Miletić V, et al. Sr,Mg co-doping of calcium hydroxyapatite: Hydrothermal synthesis, processing, characterization and possible application as dentin substitutes. Ceram Int 2022;48(8):11155–65. https://doi.org/10.1016/j.ceramint.2021.12.335

Aroni MAT, de Oliveira GJPL, Spolidório LC, et al. Loading deproteinized bovine bone with strontium enhances bone regeneration in rat calvarial critical size defects. Clin Oral Investig 2019;23(4):1605–14. https://doi.org/10.1007/s00784-018-2588-6

Qin H, Weng J, Zhou B, et al. Magnesium Ions Promote In Vitro Rat Bone Marrow Stromal Cell Angiogenesis Through Notch Signaling. Biol Trace Elem Res 2023;201(6):2823–42. https://doi.org/10.1007/s12011-022-03364-7

Yu X, Guan P-P, Zhu D, et al. Magnesium Ions Inhibit the Expression of Tumor Necrosis Factor α and the Activity of γ-Secretase in a β-Amyloid Protein-Dependent Mechanism in APP/PS1 Transgenic Mice. Front Mol Neurosci 2018; 11. https://doi.org/10.3389/fnmol.2018.00172

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