Multifunctional Sr,Mg doped mesoporous bioactive glass nanoparticles Abstract
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Abstract
Recently, mesoporous bioactive glass particles (MBGs) doped with therapeutical ions have emerged as a promising biomaterial with ability to simultaneously deliver drugs and ions, leading to synergistic outcomes. Sr and Mg ions are widely investigated in ion-doping approach of bioceramics and bioactive glasses due to their ability to stimulate osteogenesis and angiogenesis. The co-doping of MBGs with Sr and Mg might lead to accelerated bone regeneration, however the presence of dopant ions can also influence the mesoporosity of MBGNs, and thus affect bioactivity and drug release behaviour. The objective of this study was to investigate the influence of Sr,Mg co-doping on the textural properties, drug delivery, as well as pro-osteogenic and pro-angiogenic potential of MBGs.
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Funding data
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Horizon 2020 Framework Programme
Grant numbers 952033 -
Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
Grant numbers 451-03-47/2023-01/200287;451-03-47/2023-01/200135 -
Science Fund of the Republic of Serbia
Grant numbers 7470
References
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