Influence of bone substitute PerOssal® on bone marrrow mesenchymal stem cells Abstract

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Hristina Obradović
Sebastian Häusner
Drenka Trivanović
Milena Živanović
Duško Spasovski
Marietta Herrmann
Aleksandra Jauković


PerOssal® is biologically degradable and osteoconductive bone substitute consisting of nanocrystalline hydroxyapatite (51.5 %) and calcium sulfate (48.5 %). It is used for bone defect treatments as a synthetic carrier for antibiotics suitable for infected areas. Since the effect of PerOssal® has not been investigated so far in combination with mesenchymal stem cells (MSC) for bone tissue regeneration, we aimed to explore in vitro whether this material can support growth and osteogenesis of MSC from bone marrow (BM-MSC).


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Obradović, H. ., Häusner, S. ., Trivanović, D. ., Živanović, M. ., Spasovski, D. ., Herrmann, M. ., & Jauković, A. . (2024). Influence of bone substitute PerOssal® on bone marrrow mesenchymal stem cells: Abstract. HEMIJSKA INDUSTRIJA (Chemical Industry), 78(1S), 43. Retrieved from
Biomaterials for orthopedic and dental applications


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