Novel alginate/activated-charcoal platform for local treatment of resistant pathogens in wounds Abstract

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Andrea Osmokrović
Ivan Jančić
Ivona Janković-Častvan
Marina Milenković
Bojana Obradović


Antibiotic resistance is one of the biggest threats to global health, food security, and development today and new strategies to address this clinical problem are urgently needed. The aim of this work was to produce novel composites based on either Ca- or Zn-alginate hydrogels and activated charcoal (AC) particles that would, upon contact with physiological fluids, continuously release at least one bioactive agent directly into the wound area. In addition, AC particles served as carriers of other active substances such as povidone iodine (PVP-I), a very powerful antiseptic, which was used as a model substance. 


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Osmokrović, A. ., Jančić, I., Janković-Častvan, I. ., Milenković, M. ., & Obradović, B. . (2024). Novel alginate/activated-charcoal platform for local treatment of resistant pathogens in wounds: Abstract. HEMIJSKA INDUSTRIJA (Chemical Industry), 78(1S), 62. Retrieved from
Antimicrobial biomaterials and strategies

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Osmokrovic A, Jancic I, Vunduk J, Petrovic P, Milenkovic M, Obradovic B. Achieving high antimicrobial activity: composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent. Carb Pol 2018; 196: 279-88.

Osmokrovic A, Jancic I, Jankovic-Castvan I, Petrovic P, Obradovic B. Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings. Hem Ind 2019; 73 (1): 37-46.

Nesvadbova M, Crosera M, Maina G, Filon FL. Povidone iodine skin absorption: an ex-vivo study. Toxicol Lett 2015;235 (3): 155-60.

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