Two faces of biodegradable molybdenum nanoparticles regarding oxidative stress and biomedical applications Abstract
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Abstract
Recently, biodegradable metal materials have drawn a significant scientific interest owing to their attractiveness for biomedical purposes. In fact, if it were not for the presence of non-degradable metals in a human body, the risk of inflammation, infection and implant malfunction would be reduced. Molybdenum (Mo) is one of the promising materials with high potential for use in load-bearing orthopaedic and cardiovascular implants. However, upon contact with tissues and body fluids, a cascade of reactions leading to the formation of MoO3 (nano)particles (MoO3NPs) is triggered. As structures foreign to the body, they are immediately recognized by phagocytic immune cells, especially macrophages. In this work, we focused on the effects of MoO3NPs on primary human macrophages with regard to oxidative stress.
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Funding data
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Ministerstvo Zdravotnictví Ceské Republiky
Grant numbers NU20-08-00149 -
Masarykova Univerzita
Grant numbers MUNI/A/1587/2023
References
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