Determination of metal ion levels in circulation in patients with joint replacement Abstract

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Lucie Válková
Jan Emmer
Jan Kuta
Monika Pávková Goldbergová


In the past century, total joint arthroplasty has been recognized as one of the most successful and effective orthopaedic procedures. This approach, which treats mostly hip and knee joint disorders, may reduce pain, correct deformity, and improve the patient's quality of life. Materials of choice for orthopaedic implants include stainless steel, cobalt-chromium alloys, and titanium alloys. When using a metal implant, some degree of material degradation is unavoidable, which can cause issues for the patient. Various factors leading to implant deterioration are expected to result in the release of nanoparticles or ions, which can cause loosening and osteolysis. The release of oxides and metal ions can be detectable within the first few days after the alloy implantation. The tissue surrounding the implants can collect dissolved metal ions, or the ions can be discharged into bloodstream and accumulate in distant organs. The present study is focused on monitoring metal ions released from implanted material into circulation.


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Válková, L. ., Emmer, J. ., Kuta, J. ., & Pávková Goldbergová, M. . (2024). Determination of metal ion levels in circulation in patients with joint replacement: Abstract. HEMIJSKA INDUSTRIJA (Chemical Industry), 78(1S), 45. Retrieved from
Biomaterials for orthopedic and dental applications

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