Human amniotic membrane homogenate: A novel biomaterial-based strategy to impede migration and invasion of bladder cancer cells Abstract
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Abstract
Bladder cancer ranks among the top ten most frequently diagnosed cancers globally, with approximately 25 % of diagnosed cases presenting as initially aggressive muscle-invasive tumours, marked by poor prognosis and frequent metastasis. Human amniotic membrane (hAM) is an extraembryonic membrane with anti-inflammatory, antifibrotic and antimicrobial properties, however, despite the growing number of studies, the cellular mechanisms underpinning its anticancer activity remain poorly elucidated. In our investigation, we delved into the mechanisms by which hAM homogenate influences bladder cancer and normal urothelial cells.
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