Main Article Content

Vanessa Dal-Bó
Heitor Otacílio Nogueira Altino
José Teixeira Freire


The data acquisition from the freeze-drying process is important for obtaining freeze-dried samples with the desired final moisture content under various operating conditions. The current study extensively presents a simple and low-cost methodology for implementing a data acquisition system in a laboratory-scale freeze dryer. The results showed that higher drying temperatures (40 °C) increased the errors involved in measuring the mass of material; nevertheless, the application of correction blank curves statistically significantly reduced those errors. In general, the system developed provided precise and accurate measurements of the temporal changes in the sample mass and temperature, and chamber pressure variations, allowing monitoring of the production process of freeze-dried samples with low final moisture contents.

Article Details

How to Cite
Dal-Bó, V. ., Nogueira Altino, H. O. ., & Freire, J. T. . (2023). SYSTEM DEVELOPMENT FOR MONITORING THE PRODUCTION PROCESS OF FREEZE-DRIED SAMPLES: A SIMPLE AND LOW-COST APPROACH: Original scientific paper. Chemical Industry & Chemical Engineering Quarterly, 30(2), 111–122.


G. Caliskan, S.N. Dirim, Heat Mass Transfer 53 (2017) 2129—2141.

Y. Wang, X. Li, X. Chen, B. Li, X. Mao, J. Miao, C. Zhao, L. Huang, W. Gao, Chem. Eng. Process. 129 (2018) 84—94.

E. Lopez-Quiroga, L.T. Antelo, A.A. Alonso, J. Food Eng. 111 (2012) 655—666.

L.G. Marques, M.C. Ferreira, J.T. Freire, Chem. Eng. Process. 46 (2007) 451—457.

R.L. Monteiro, B.A.M. Carciofi, A. Marsaioli, J.B. Laurindo, J. Food Eng. 166 (2015) 276—284.

A.S. Mujumdar, Handbook of Industrial Drying, CRC Press, Boca Raton, (2014), p. 1352.

X.C. Tang, M.J. Pikal, Pharm. Res. 21 (2004) 191—200.

V. Dal-Bó, J.T. Freire, Food Control. 132 (2022) 108526.

A. Carullo, A. Vallan, Measurement 45 (2012) 1706—1712.

G. Tribuzi, J.B. Laurindo, Dry. Technol. 32 (2014) 1119—1124.

V. Kirrmaci, H. Usta, T. Menlik, Dry. Technol. 26 (2008) 1570—1576.

J.P. George, A.K. Datta, J. Food Eng. 52 (2002) 89—93.

T. Menlik, M.B. Özdemir, V. Kirmaci, Expert Syst. Appl. 37 (2010) 7669—7677.

C. Moino, E. Bourlés, R. Pisano, B. Scutellà, Ind. Eng. Chem. Res. 60 (2021) 9637—9645.

S.C. Schneid, H. Gieseler, W.J. Kessler, S.A. Luthra, M.J. Pikal, AAPS PharmSciTech. 12 (2011) 379—387.

X. (Charlie) Tang, S.L. Nail, M.J. Pikal, Pharm. Res. 22 (2005) 685—700.

P. Chouvenc, S. Vessot, J. Andrieu, P. Vacus, Dry. Technol. 22 (2004) 1577—1601.

R. Daoussi, S. Vessot, J. Andrieu, O. Monnier, Chem. Eng. Res. Des. 87 (2009) 899—907.

S.A. Velardi, H. Hammouri, A.A. Barresi, Chem. Eng. Res. Des. 87 (2009) 1409—1419.

C. Vilas, A.A. Alonso, E. Balsa-Canto, E. López-Quiroga, I.C. Trelea, Processes 8 (2020) 1—21.

R. Pisano, Dry. Technol. 40 (2022) 140—157.

A.A. Barresi, R. Pisano, D. Fissore, V. Rasetto, S.A. Velardi, A. Vallan, M. Parvis, M. Galan, Chem. Eng.

Process. Process Intensif. 48 (2009) 408—423.

A. Vallan, Instrumentation and Measurement Technology Conference, in Proceeding of IEEE Instrumentation & Measurement Technology Conference, Warsaw, Poland, (2007). p. 1—5.

M.J. Pikal, S. Shah, D. Senior, J.E. Lang, J. Pharm. Sci. 72 (1983) 635—650.

C. Roth, G. Winter, G. Lee, J. Pharm. Sci. 90 (2001) 1345—1355.

J. Xiang, J.M. Hey, V. Liedtke, D.. Wang, Int. J. Pharm. 279 (2004) 95—105.

D. Fissore, R. Pisano, A.A. Barresi, Dry. Technol. 36 (2018) 1839—1865.

G. Rovero, S. Ghio, A.A. Barresi, Chem. Eng. Sci. 56 (2001) 3575—3584.

S. Grassini, S. Corbellini, M. Parvis, E. Angelini, F. Zucchi, Meas.: J. Int. Meas. Confed. 114 (2018) 508—514.

V.D. Sabadoti, A.C. Miano, P.E.D. Augusto, J. Food Process. Preserv. 44 (2020) 1—10.

O.I. Obajemihi, J.O. Olaoye, J.H. Cheng, J.O. Ojediran, D.W. Sun, J. Food Process. Preserv. 45 (2021) 1—14.

A. D’Ausilio, Behav. Res. Methods 44 (2012) 305—313.

A. Kilpela, Pulsed time-of-flight laser range finder techniques for fast, high precision measurement applications, University of Oulu, (2004) p. 98.

X. Li, B. Yang, X. Xie, D. Li, L. Xu, Sensors (Switzerland). 18 (2018) 1—16.

AOAC, Official methods of analysis of Association of Official Analytical Chemists, AOAC, Arlington (1990), p. 771. ISBN 0-935584-42-0.

P. Jacobs, Thermodynamics, Imperial College Press, London (2013), p. 456. ISBN 184816971X.

W. Yang, D.E.O. III, R.O.W. III, in Formulating Poorly Water Soluble Drugs, R.O. Williams III, A. B. Watts, D. A. Miller, Springer, New York (2012), p. 646.

A. Bhushani, C. Anandharamakrishnan, in Handbook of Drying for Dairy Products, C. Anandharamakrishnan, John Wiley & Sons, Chichester (2017) p. 316.

O. Taskin, Heat Mass Transfer 56 (2020) 2503—2513.

T. Kovacı, E. Dikmen, A.Ş. Şahin, J. Food Process Eng. 43 (2020) 1—9.

L.L. Huang, M. Zhang, A.S. Mujumdar, D.F. Sun, G.W. Tan, S. Tang, Dry. Technol. 27 (2009) 938—946.

I. Dincer, M.A. Rosen, Energy, Environment and Sustainable Development, Springer, Vienna, (2012) p. 349.

Y.A. Çengel, M.A. Boles, Thermodynamics: an engineering approach, Mc Graw Hill Education, New York, (2014) p. 1024. ISBN 9780073398174.

A. Midilli, H. Kucuk, Z. Yapar, Dry. Technol. 20 (2002) 1503–1513.

T. Kopczynski, Five Factors That Can Affect Your Weighing System’s Accuracy, Hardy, San Diego, (2011).

C.D. Johnson, Process Control Instrumentation Technology, Pearson Education Limited, Harlow, (2013) p. 684. ISBN 9781292026015.

A.L. Silva, M. Varanis, A.G. Mereles, C. Oliveira, J.M. Balthazar, Rev. Bras. Ensino Fis. 41 (2019).

A.R. Gorbushin, A.A. Bolshakova, Measurement 152 (2020) 107381.

W. Hernandez, Sensors 6 (2006) 697—711.

I. Muller, R. De Brito, C.E. Pereira, V. Brusamarello, IEEE Instrum. Meas. Mag. 13 (2010) 15—19.

A. Karaus, H. Paul, Measurement 10 (1992) 133—139.

G. Levi, M. Karel, Food Res. Int. 28 (1995) 145—151.

M.J. Pikal, S. Shah, Int. J. Pharm. 62 (1990) 165—186.

D.S. Souza, L.G. Marques, E. de B. Gomes, N. Narain, Dry. Technol. 33 (2015) 194—204.

R.J. Brandão, M.M. Prado, L.G. Marques, Defect Diffus. Forum 365 (2015) 11—16.

K. Altay, A.A. Hayaloglu, S.N. Dirim, Heat Mass Transfer 55 (2019) 2173—2184.

W. Liu, M. Zhang, B. Adhikari, J. Chen, Innov. Food Sci. Emerg. Technol. 66 (2020) 102516.

X. Duan, X. Yang, G. Ren, Y. Pang, L. Liu, Y. Liu, Dry. Technol. 34 (2016) 1271—1285.

X. Cao, M. Zhang, A.S. Mujumdar, Q. Zhong, Z. Wang, Ultrason. Sonochem. 40 (2018) 333—340.

T. Baysal, N. Ozbalta, S. Gokbulut, B. Capar, O. Tastan, G. Gurlek, F. Engineering, M. Engineering, K. Tarihi, J. Therm. Sci. Technol. 35 (2015) 135—144.

Most read articles by the same author(s)