Effects of different doped hydroxyapatite‐based materials on healing of critical size calvaria bone defects in rats Abstract

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Objavljeno: mar 29, 2024
Ključne reči:
Biomedical application, tricalcium phosphate, bone regeneration, in vivo

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Nikola Busarać
Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Irena Kasalović
Department of Dentistry, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
https://orcid.org/0000-0002-3716-4143
Suzana Živanović
Department of Dentistry, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Tamara Matić
Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia
https://orcid.org/0000-0002-7415-0453
Đorđe Veljović
University of Belgrade, Faculty of Technology and Metallurgy, Belgrade, Serbia
https://orcid.org/0000-0001-6370-7167
Biljana Ljujić
Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
https://orcid.org/0000-0002-6759-2720
Miloš Papić
Department of Dentistry, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia

Apstrakt

Nanosized synthetic hydroxyapatite (HAp), closely resembling biological apatite found in human bones and teeth, is extensively studied for its potential in hard tissue repair. Ion-doping of HAp with therapeutic ions is emerging as a promising strategy to mimic biological apatite, promoting specific biological responses such as osteogenesis, angiogenesis, increased cell proliferation, and antimicrobial activity. The aim of our study was to explore and compare the effects of Sr,Cu co-doped α tricalcium phosphate (αTCP) with/without Mg doped HAP on healing of critical size rat calvaria defects in vivo.

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Kako citirati
Busarać, N. ., Kasalović, I. ., Živanović, S. ., Matić, T. ., Veljović, Đorđe ., Ljujić, B. ., & Papić, M. . (2024). Effects of different doped hydroxyapatite‐based materials on healing of critical size calvaria bone defects in rats: Abstract. HEMIJSKA INDUSTRIJA : : ХЕМИЈСКА ИНДУСТРИЈА, 78(1S), 38. преузето од https://www.ache-pub.org.rs/index.php/HemInd/article/view/1282
Broj časopisa
God. 78 Br. 1S (2024): Supplementary Issue - ExcellMater Conference 2024
Sekcija
Biomaterials for orthopedic and dental applications
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Ovaj rad je pod Creative Commons Aуторство-Nekomercijalno-Bez prerade 4.0 Internacionalna licenca.

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Reference

Matić T, Zebić ML, Miletić V, et al. Sr,Mg co-doping of calcium hydroxyapatite: Hydrothermal synthesis, processing, characterization and possible application as dentin substitutes. Ceram Int 2022;48(8):11155–65. https://doi.org/10.1016/j.ceramint.2021.12.335

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Yu X, Guan P-P, Zhu D, et al. Magnesium Ions Inhibit the Expression of Tumor Necrosis Factor α and the Activity of γ-Secretase in a β-Amyloid Protein-Dependent Mechanism in APP/PS1 Transgenic Mice. Front Mol Neurosci 2018; 11. https://doi.org/10.3389/fnmol.2018.00172

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