Peculiarities of alginate gellation triggered by calcium ions in the presence of hydroxyapatite particles Abstract

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Katarina Dimić-Mišić
Ivana Banićević
Bojana Obradović
https://orcid.org/0000-0002-7276-0442
Michael Gasik

Apstrakt

Hydroxyapatite (HAP), a crucial constituent of natural bone mineral, significantly enhances the osteoconductivity of alginate hydrogels (AH) in biodegradable composites mimicking the mineral composition, porosity, and mechanical properties of bone tissue. Ionic crosslinking of sodium alginate hydrogels with Ca+ ions result in the rapid formation of egg-box structures, leading to enthalpy-driven hydration and dehydration mechanisms observable through swelling and subsequent shrinkage of the crosslinked aerogel. The fast shrinkage induces non-linear sizing of water-containing pockets, impacting the unilinear pore size distribution of freeze-dried aerogels, thereby influencing the porosity and mechanical properties of the final scaffolds.

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Kako citirati
Dimić-Mišić, K., Banićević, I. ., Obradović, B. ., & Gasik, M. . (2024). Peculiarities of alginate gellation triggered by calcium ions in the presence of hydroxyapatite particles: Abstract. HEMIJSKA INDUSTRIJA : : ХЕМИЈСКА ИНДУСТРИЈА, 78(1S), 31. преузето од https://www.ache-pub.org.rs/index.php/HemInd/article/view/1274
Sekcija
Polymer gels and composites for biomedical applications

Funding data

Reference

Stojkovska J, Zvicer J, Andrejevic, M, Janackovic D, Obradovic B, Veljovic D. Novel composite scaffolds based on alginate and mg‐doped calcium phosphate fillers: enhanced hydroxyapatite formation under biomimetic conditions. Journal of biomedical materials research part b: applied biomaterials.2021; 109: 2079-2090. https://doi.org/10.1002/jbm.b.34856

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