Evaluation of crosslinked gelatin-polyvinylpyrrolidone scaffold for application in drug delivery and tissue engineering Abstract

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Objavljeno: mar 29, 2024
Ključne reči:
3D printing, semi-solid extrusion, genipin, mechanical testing: cytotoxicity, cytotoxicity

Glavni sadržaj članka

Marija Jovanović
University of Belgrade - Faculty of Technology and Metallurgy, Karnegijeva 4, 11120 Belgrade, Serbia
Miloš Petrović
University of Belgrade - Faculty of Technology and Metallurgy, Karnegijeva 4, 11120 Belgrade, Serbia
https://orcid.org/0000-0002-2460-7793
Dušica Stojanović
University of Belgrade - Faculty of Technology and Metallurgy, Karnegijeva 4, 11120 Belgrade, Serbia
https://orcid.org/0000-0001-6308-7586
Nataša Nataša Radulović
Institute for Biological Research “Siniša Stankovic ́” - National Institute of the Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11108 Belgrade, Serbia
Danijel Pantelić
Institute for Biological Research “Siniša Stankovic ́” - National Institute of the Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11108 Belgrade, Serbia
Vesna Radojević
University of Belgrade - Faculty of Technology and Metallurgy, Karnegijeva 4, 11120 Belgrade, Serbia
Petar Uskoković
University of Belgrade - Faculty of Technology and Metallurgy, Karnegijeva 4, 11120 Belgrade, Serbia

Apstrakt

The objective of this study was to process and evaluate a suitable scaffold matrix system for drug delivery and tissue regeneration. A bioinspired approach was applied. The scaffold based on natural polymer gelatin, blended with polyvinylpyrrolidone, and crosslinked by genipin, was 3D printed by semi-solid extrusion (SSE). This 3D printing technique does not require high temperature or UV curing, so it allows the use of thermo- and UV-sensitive drugs, cells, or other biological components. The influence of genipin, a natural crosslinking agent, and its content on the mechanical properties and the cytotoxicity of obtained scaffolds were investigated.

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Kako citirati
Jovanović, M. ., Petrović, M. ., Stojanović, D. ., Nataša Radulović, N. ., Pantelić, D. ., Radojević, V. ., & Uskoković, P. . (2024). Evaluation of crosslinked gelatin-polyvinylpyrrolidone scaffold for application in drug delivery and tissue engineering: Abstract. HEMIJSKA INDUSTRIJA : : ХЕМИЈСКА ИНДУСТРИЈА, 78(1S), 25. преузето од https://www.ache-pub.org.rs/index.php/HemInd/article/view/1268
Broj časopisa
God. 78 Br. 1S (2024): Supplementary Issue - ExcellMater Conference 2024
Sekcija
Polymer gels and composites for biomedical applications
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Ovaj rad je pod Creative Commons Aуторство-Nekomercijalno-Bez prerade 4.0 Internacionalna licenca.

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Reference

Jovanović M, Petrović M, Cvijić S, Tomić N, Stojanović D, Ibrić S, Uskoković P. 3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction. Pharmaceutics 2021; 13: 2143. https://doi.org/10.3390/pharmaceutics13122143

Rao Z, Dong Y, Liu J, Zheng X, Pei Y., Tang K. Genipin-crosslinked gelatin-based composite hydrogels reinforced with amino-functionalized microfibrillated cellulose. Int. J. Biol. Macromol 2022; 222: 3155. https://doi.org/10.1016/j.ijbiomac.2022.10.088