Improving the viability and stability of a probiotic product with Saccharomyces boulardii DBVPG
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Abstract
In recent decades, probiotic products have been increasingly used to prevent certain gastrointestinal and urogenital disorders, to improve the general condition of the body and as a supplement to pharmacological therapy. They are most often registered as dietary supplements, and less often as drugs in the form of capsules, powders, and solutions. Optimization of technological processes of production and packaging of these products aims to maintain probiotic characteristics while adhering to all criteria during production that ensure quality, bioavailability and optimal therapeutic effects. In this paper, the importance of choosing primary and secondary packaging materials was explored with the aim of preserving the viability of probiotic cells in capsules for two years, i.e. during the shelf life. By comparing the applications of polyvinyl chloride (PVC) and PVC/polyvinylidene chloride/polyethylene blister foils, better protection of probiotic cells was observed by applying the multilayer foil. In addition, in this research, further improvements of probiotic cell protection were achieved by applying a secondary packing-flow pack bag with inert gas for storing multilayered blisters.
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References
World Health Organization. Probiotics in food, Health and nutritional properties and guidelines for evaluation. Rome, Italy: FAO; 2001.
Salminen S, Ouwehand AC, Isolauri E. Clinical Applications of Probiotic Bacteria. Int Dairy J 1998; 8: 563-572.
Alvarez MJ, Oberhelman RA. Probiotic Agents and Infectious Disease: A modern Perspective on a Traditional Therapy. Clin Infect Dis 2001; 32: 1567-1576.
Goktepe I, Juneja VK, Ahmedna M. Probiotics in food safety and human health. Boca Raton, USA: Taylor & Francis Group, LLC; 2006.
Saarela MH. Probiotic technology Maintaining viability and stability. Agro Food Industry Hi Tech 2007; 18: 19-21.
Uddin MS, al Mamun A, Rashid M, Asaduzzaaman M. In-process and Finished Products Quality Control Tests for Pharmaceutical Capsules According to Pharmacopoeias. British J Pharm Res. 2015; 9: 1-9.
Dao H, Lakhani P, Police A, Kallakunta V, Ajjarapu SS, Wu K-W, Ponkshe P, Repka MA, Murthy SN. Microbial Stability of Pharmaceutical and Cosmetic Products. AAPS, Pharm SciTech. 2018; 19: 60-78.
Das S, Bhattacharjee D, Manna A, Basu S. Effect of Different Excipients and packaging Materials on Commercial Preparation of Probiotic Formulation. Int J Pharm Pharm Sci. 2014; 5: 1830-1836.
Kolaček S, Hojsak I, Canani RB, Guarino A, Indrio F, Orel R, Pot B, Shamir R, Szajewska H, Vandenplas Y, van Goudoever J, Weizman Z, ESPGHAN Working Group for Probiotics and Prebiotics. Commercial Probiotic Products: A Call for Improved Quality Control. A Position Paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr. 2017; 65: 117-124.