Multi-walled carbon nanotubes as lipase carriers for organic synthesis: current trends and recent update Review paper

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Nevena Prlainović
Jelena Milovanović
Nikola Milašinović
Dejan Bezbradica
Dušan Mijin


Lipase-catalyzed organic reactions have been widely practiced in the past three decades. Especially interesting are insoluble/immobilized forms due to providing a possibility of facile use and recyclability, thus reducing process costs, and making the procedure more environmentally friendly. Carbon-based supports have been extensively exploited for this purpose, because of neutral and biodegradable nature and thermal and chemical stability. Their high specific surface area, characteristic surface morphology and lower mass transfer resistances play a vital role in the performance of the attached enzyme. This review paper presents an overview of the main aspects of lipase immobilized on multi-walled carbon nanotubes (MWCNTs). Moreover, different immobilization strategies to achieve a biocatalyst with improved performances are discussed. Furthermore, as lipases are considered to have high commercial worth for synthesis of valuable organic molecules, the second part of the paper is dedicated to the overview of the most important industrial sectors in which these nanobiocatalysts have been used. In specific, applications in biodiesel production, flavour ester synthesis and racemization are summarized.


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Prlainović, N., Milovanović, J. ., Milašinović, N., Bezbradica, D. ., & Mijin, D. (2024). Multi-walled carbon nanotubes as lipase carriers for organic synthesis: current trends and recent update : Review paper. HEMIJSKA INDUSTRIJA (Chemical Industry), 78(1), 1–16.
Applied Chemistry


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