Stability of liposomal particles with encapsulated coumarin derivate Abstract

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Aleksandra A. Jovanović
Edina Avdović
Ana Plećić
Natalija Čutović
Branko Bugarski
Zoran Marković


Coumarin derivates possess several biological effects, including anti-inflammatory, antioxidant, anticoagulant, antitumor, insecticidal, anthelminthic, hypnotic, antifungal, and HIV protease inhibition properties. Due to their solubility in organic solvents and insolubility in water and body fluids, their bioavailability is significantly low. Thus, they can be encapsulated into liposomal particles with the aim of overcoming the mentioned disadvan­tage. Hence, in the present study, coumarin derivate was encapsulated in phospholipid liposomes and their stability was monitored for 60 days in terms of vesicle size, polydispersity index (PDI), zeta potential, and mobility.


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Jovanović, A. A. ., Avdović, E. ., Plećić, A. ., Čutović, N. ., Bugarski, B. ., & Marković , Z. . (2024). Stability of liposomal particles with encapsulated coumarin derivate: Abstract. HEMIJSKA INDUSTRIJA (Chemical Industry), 78(1S), 66. Retrieved from
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