Stability of liposomal particles with encapsulated coumarin derivate Abstract
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Abstract
Coumarin derivates possess several biological effects, including anti-inflammatory, antioxidant, anticoagulant, antitumor, insecticidal, anthelminthic, hypnotic, antifungal, and HIV protease inhibition properties. Due to their solubility in organic solvents and insolubility in water and body fluids, their bioavailability is significantly low. Thus, they can be encapsulated into liposomal particles with the aim of overcoming the mentioned disadvantage. Hence, in the present study, coumarin derivate was encapsulated in phospholipid liposomes and their stability was monitored for 60 days in terms of vesicle size, polydispersity index (PDI), zeta potential, and mobility.
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References
Kirkiacharian, B.S., De Clercq, E., Kurkjian, R., Pannecouque, C. New synthesis and anti-HIV and antiviral properties of 3-arylsulfonyl derivatives of 4-hydroxycoumarin and 4-hydroxyquinolone. Pharm. Chem. J. 2008; 42: 265-270.
Kontogiorgis, C.A., Hadjipavlou-Litina, D.J. Synthesis and antiinflammatory activity of coumarin derivatives. J. Med. Chem. 2005; 48: 6400. https://doi.org/10.1021/jm0580149
Jovanović, A., Balanč, B., Ota, A., Pegi, A., Djordjević, V., Šavikin, K., Bugarski, B., Nedović, V., Poklar-Ulrih, N. Comparative Effects of Cholesterol and β-Sitosterol on the Liposome Membrane Characteristics. Eur. J. Lipid Sci. Technol. 2018; 120: 1–41.
Isailović, B., Kostić, I., Zvonar, A., Đorđević, V., Gašperlin, M., Nedović, V., Bugarski, B. Resveratrol loaded liposomes produced by different techniques. Innov. Food Sci. Emerg. Technol. 2013; 19: 181-189. https://doi.org/10.1016/j.ifset.2013.03.006
Ardani, H.K., Imawan, C., Handayani, W., Djuhana, D., Harmoko, A., Fauzia, V. Enhancement of the stability of silver nanoparticles synthesized using aqueous extract of Diospyros discolor Willd. leaves using polyvinyl alcohol. IOP Conf. Ser.: Mater. Sci. Eng. 2017; 188: 012056. https://doi.org/10.1088/1757-899X/188/1/012056